What Is Oxycodone
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Oxycodone is a semi-synthetic opioid painkiller. Cleveland Clinic+3NCBI+3Wikipedia+3
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It’s used for moderate to severe pain, especially when other, less strong pain medicines are not sufficient. NCBI+3MedlinePlus+3CAMH+3
How It Works
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It binds to opioid receptors in the brain and spinal cord, reducing perception of pain. NCBI+1
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Also produces effects like sedation, euphoria, slowed breathing, suppression of cough reflex. DEA+2NCBI+2
Forms & Release Types
Oxycodone pills can come in a few different forms:
Type | Description / Onset / Duration |
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Immediate-release (IR) | Acts quickly (30-60 minutes or so), effects last for ~4-6 hours. Used for breakthrough pain. nhs.uk+1 |
Extended-release / controlled-release | Releases the drug more slowly over a longer period for continuous pain relief. Not for acute spikes of pain. Must be swallowed whole, not crushed. FDA Access Data+2Cleveland Clinic+2 |
Some products are combinations with other pain-relievers (e.g. oxycodone + acetaminophen / paracetamol, or oxycodone + NSAIDs) to increase pain control. Wikipedia+2CAMH+2
Typical Strengths
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Different strengths exist depending on whether it’s IR or extended-release. For example, the brand OxyContin (a well-known extended-release version) comes in tablet strengths of 10 mg, 20 mg, 40 mg, 80 mg, 160 mg, with the higher ones reserved for people who already have tolerance
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IR pills have smaller doses and more frequent dosing (e.g. every 4-6 hours) versus once or twice daily for extended-release. nhs.uk+1
Risks, Side Effects & Safety
Because oxycodone is a powerful opioid, there are many risks:
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Common side effects: Constipation, nausea, sleepiness, dizziness, vomiting, dry mouth. Wikipedia+2MedlinePlus+2
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Serious risks:
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Respiratory depression (especially dangerous if starting treatment, increasing dose, or combining with other depressants like alcohol/sedatives). MedlinePlus+2DEA+2
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Addiction, dependence, misuse risk is high. MedlinePlus+2NCBI+2
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Withdrawal symptoms if stopped suddenly after long-term use. Mayo Clinic+1
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Other concerns: Tolerance (you need more for same effect over time), potential for hyperalgesia (pain sensitivity), interactions with other drugs. nhs.uk+1
Important Usage/Regulation Notes
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Oxycodone is prescription-only in almost all countries. Strict controls generally apply (special scheduling, monitoring) because of abuse potential. CAMH+3DEA+3Wikipedia+3
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Patients are often given careful instructions: how to take the pills (IR vs ER), not to crush or chew extended-release versions, avoid mixing with alcohol or other sedatives. MedlinePlus+2Cleveland Clinic+2
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Dosing must be individualised based on pain level, prior opioid use, kidney/liver function etc.